Molecular basis for acceptor substrate specificity of the human β1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively
نویسندگان
چکیده
منابع مشابه
Molecular basis for acceptor substrate specificity of the human b1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively
Magali Fondeur-Gelinotte2, Virginie Lattard2, Sandrine Gulberti2, Rafael Oriol4, Guillermo Mulliert3, Michael WH Coughtrie5, Jacques Magdalou2, Patrick Netter2, Mohamed Ouzzine2, and Sylvie Fournel-Gigleux1,2 UMR 7561, and UMR 7036 CNRS-Université Henri Poincaré Nancy 1, Faculté de Médecine, BP 184, 54505 Vandœuvre-lès-Nancy, France; INSERM U602, Université de Paris Sud XI, 94807 Villejuif, Fra...
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HNK-1 (human natural killer-1) carbohydrate epitope (HSO(3)-3GlcAβ1-3Galβ1-4GlcNAc-) recognized by a HNK-1 monoclonal antibody is highly expressed in the nervous system and biosynthesized by a glucuronyltransferase (GlcAT-P or GlcAT-S), and sulfotransferase (HNK-1ST). A similar oligosaccharide (HSO(3)-3GlcAβ1-3Galβ1-3Galβ1-4Xyl) also recognized by the HNK-1 antibody had been found in a glycosam...
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Human natural killer-1 (HNK-1) carbohydrate (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-R) is highly expressed in the brain and required for learning and neural plasticity. We previously demonstrated that expression of the HNK-1 epitope is mostly abolished in knockout mice for GlcAT-P (B3gat1), a major glucuronyltransferase required for HNK-1 biosynthesis, but remained in specific regions such as perineuronal...
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HNK-1 epitope is a cell-surface carbohydrate mediating various cell-cell or cell-substrate interactions. We found HNK-1 epitope in longitudinally arrayed fibers in the subpopulation of the epaxial myotome, and hypaxial myoblasts migrating into the limb bud in the rat embryo. We next investigated the expression patterns of genes encoding two glucuronyltransferases (GlcAT-P, GlcAT-D) and sulfotra...
متن کاملStructural and biochemical characterization of O-mannose-linked human natural killer-1 glycan expressed on phosphacan in developing mouse brains.
The human natural killer-1 (HNK-1) carbohydrate comprising a sulfated trisaccharide (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-) is expressed on N-linked and O-mannose-linked glycans in the nervous system and involved in learning and memory functions. Although whole/core glycan structures and carrier glycoproteins for the N-linked HNK-1 epitope have been studied, carrier glycoproteins and the biosynthetic pa...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2007
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwm055